GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2275426 | 1 | rs4545281 | chr1:46360054 | MMACHC | chr1:45965856-45976737:+ | -0.2 | -4.48 | 9.17E-6 | Body mass index |
| THCA | cis | rs2275426 | 1 | rs4545281 | chr1:46360054 | MUTYH | chr1:45794915-45806142:- | 0.32 | 8.59 | 1.24E-16 | Body mass index |
| THCA | cis | rs6011674 | 1 | rs45469101 | chr20:61875007 | BIRC7 | chr20:61867276-61871853:+ | 0.36 | 4.22 | 2.95E-5 | Response to cytadine analogues (cytosine arabinoside) |
| THCA | cis | rs6011674 | 1 | rs45469101 | chr20:61875007 | NKAIN4 | chr20:61872137-61885892:- | 0.37 | 3.9 | 0.000111 | Response to cytadine analogues (cytosine arabinoside) |
| THCA | cis | rs12780845 | 1 | rs45472399 | chr10:17209967 | TRDMT1 | chr10:17184983-17243681:- | -0.44 | -10.32 | 1.08E-22 | Homocysteine levels |
| THCA | cis | rs12780845 | 1 | rs45472399 | chr10:17209967 | VIM | chr10:17270258-17279592:+ | -0.19 | -3.52 | 0.000466 | Homocysteine levels |
| THCA | cis | rs7665090 | 1 | rs4547797 | chr4:103557192 | CISD2 | chr4:103790135-103809913:+ | -0.16 | -3.62 | 0.000321 | Primary biliary cirrhosis |
| THCA | cis | rs7665090 | 1 | rs4547797 | chr4:103557192 | NFKB1 | chr4:103422486-103538458:+ | 0.15 | 4.2 | 3.16E-5 | Primary biliary cirrhosis |
| THCA | cis | rs2243480 | 1 | rs4548056 | chr7:65298873 | CCT6P1 | chr7:65216092-65228661:+ | 0.39 | 6.13 | 1.83E-9 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs4548056 | chr7:65298873 | CRCP | chr7:65579805-65619551:+ | -0.26 | -4.07 | 5.41E-5 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs4548056 | chr7:65298873 | RABGEF1 | chr7:66093890-66276446:+ | 0.54 | 6.68 | 6.63E-11 | Diabetic kidney disease |
| THCA | cis | rs4372836 | 1 | rs4549034 | chr2:28972579 | PPP1CB | chr2:28974612-29025805:+ | 0.17 | 4.16 | 3.82E-5 | Body mass index |
| THCA | cis | rs4372836 | 1 | rs4549034 | chr2:28972579 | TRMT61B | chr2:29072690-29093175:- | -0.51 | -10.21 | 2.93E-22 | Body mass index |
| THCA | cis | rs11723261 | 1 | rs4549329 | chr4:239785 | ZNF718 | chr4:53272-156488:+ | 0.52 | 10.26 | 1.82E-22 | Immune response to smallpox vaccine (IL-6) |
| THCA | cis | rs12134663 | 1 | rs45504202 | chr1:11858550 | MTHFR | chr1:11845787-11866115:- | 0.23 | 3.45 | 0.000615 | Homocysteine levels |